Published on
December 15, 2023

Fad Diets: Uncovering the Truth Behind Trendy Eating Plans

Dive into the world of fad diets to discover their health impacts, benefits, and myths. A comprehensive guide to understanding trendy diets.

Fad Diets
Fad Diets: Uncovering the Truth Behind Trendy Eating Plans

Fad diets often spotlighted for their promise of rapid weight loss and health transformation, have become a cornerstone of contemporary dietary trends.

This article delves into the multifaceted world of fad diets, exploring various aspects from weight loss effectiveness and dietary plans to nutrition myths and balanced eating.

It aims to demystify the health benefits and potential risks associated with these lifestyle diets, offering sound dietary advice.

By examining both the allure and the pitfalls of these dietary fads, readers are guided toward a more informed and healthy approach to eating.

Main Findings

  • Diverse Diet Reviews: Analysis of various popular diets, including Atkins, Ketogenic, and Mediterranean.
  • Effectiveness and Risks: Evaluation of each diet’s health benefits and potential dangers.
  • Weight Management Insights: Insights into how these diets impact weight loss and management.
  • Nutritional Balances: Discussion on the nutritional adequacy and deficiencies in these diets.
  • Sustainability and Practicality: Examination of the long-term sustainability of these diets.
  • Myth Debunking: Addressing common misconceptions about these diets.

Introduction

Navigating Fad Diets: Balancing Health Trends and Risks

Obesity has become a global epidemic, affecting people of all backgrounds and ages.

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Despite the growing obesity crisis, many individuals are turning to fad diets in search of quick fixes.

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Fad diets, while not a scientific term, are trendy dietary patterns promising rapid weight loss.

They typically lack guidelines for physical activity, focus on short-term changes rather than sustainable goals, eliminate entire food groups, and often lack nutritional adequacy A Trusted Source

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These diets rarely provide health warnings for those with chronic diseases and often lack scientific evidence to support their claims A Trusted Source

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Exploring Popular Diets

Various types of FDs have been suggested so far, including low-carb diets, low-fat diets, high-fat diets, high-protein diets, detoxifying diets, and diets based on the Mediterranean or Paleolithic lifestyles.

People often follow these diets without considering individual differences, which can lead to negative health effects.

This review will examine the existing evidence regarding the health effects of several popular diets, such as the Atkins diet, ketogenic diet, Paleolithic diet, Mediterranean diet, vegetarian diet, intermittent fasting, and detox diet.

Atkins Diet (AD)

In the 1970s, Dr. Robert Atkins introduced the low-carbohydrate, high-protein (LCHP) Atkins Diet, emphasizing lifelong dietary changes A Trusted Source

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Atkins believed that carbs were the main cause of obesity and promoted a high-energy diet, with less than 5% of calories from carbs, free protein and fat intake, fluids, vitamins, minerals, and exercise A Trusted Source

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The Atkins Diet has four phases: induction, ongoing weight loss, pre-maintenance, and lifetime maintenance, with a modified version allowing some flexibility A Trusted Source

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Research suggests that it leads to more weight loss compared to conventional diets.

In one study, LCHP dieters lost 8.5 kg in six months versus 4.2 kg for low-fat dieters A Trusted Source

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Similarly, another trial found LCHP individuals lost 3.8 kg more than low-fat dieters over six months A Trusted Source

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Meta-analyses confirm that low-carb diets yield greater weight loss and improved cardiovascular risk factors A Trusted Source

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However, studies report no significant long-term differences in cardiovascular or diabetes risk factors between low-carb and balanced diets A Trusted Source

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Very low carbohydrate diets (<50 g/day) show better results in improving lipid profiles and blood pressure A Trusted Source

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While effective for weight loss, concerns exist, especially for those with comorbidities.

LCHP diets may increase the risk of urinary stone formation and chronic kidney disease A Trusted Source

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Metabolic acidosis, a common complication, can lead to ketoacidosis, especially in pregnant and lactating women A Trusted Source

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Ketogenic Diet (KD)

In 1923, Dr. Russell Wilder introduced the classic Ketogenic Diet (KD) as a treatment for epilepsy.

This diet, which remains popular today, emphasizes a strict regimen with a 4:1 ratio of fats to a combination of carbohydrates and proteins A Trusted Source

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The KD has evolved, with five types in medical literature: classic keto, modified keto, medium-chain triglycerides oil, low glycemic index treatment, and modified Atkins diet.

These diets differ in their macronutrient ratios, but the common thread is very low carbohydrate intake (5-10% of calories), moderate protein (20-25%), and high fat (65-80%) A Trusted Source

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The KD triggers metabolic changes in the body.

By depriving the body of carbohydrates, it shifts toward gluconeogenesis and ketogenesis.

In gluconeogenesis, the body produces glucose from sources like glycerol and amino acids, while ketone bodies serve as an alternative energy source A Trusted Source

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This metabolic state remains until carbohydrate needs are met.

Research consistently shows that KD is effective in improving the quality of life, seizure severity, and frequency in epileptic patients A Trusted Source

Kverneland M, Molteberg E, Iversen PO, Veierød MB, Taubøll E, Selmer KK, et al. Effect of modified atkins diet in adults with drug-resistant focal epilepsy: a randomized clinical trial. Epilepsia. (2018) 59:1567–76. doi: 10.1111/epi.14457[PubMed Abstract, CrossRef Full Text, Google Scholar]
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It also exhibits neuroprotective effects in conditions such as Alzheimer's disease, Parkinson's disease, and traumatic brain injury A Trusted Source

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In recent times, it has gained recognition as a weight loss intervention, with studies reporting mixed findings.

One study comparing a low-carb ketogenic diet (LCKD) to a medium-carb non-ketogenic diet (MCNKD) found greater weight loss and reduced hunger in the LCKD group after four weeks A Trusted Source

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A meta-analysis concluded that KD contributes to greater long-term weight loss compared to low-fat diets A Trusted Source

Bueno NB, de Melo SIV, De Oliveira SL, da Rocha Ataide T. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. (2013) 110:1178–87. doi: 10.1017/S0007114513000548[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Another study comparing KD to a hypocaloric diet (HCD) showed significant differences in weight loss, fat mass, waist circumference, fasting insulin, and high molecular weight adiponectin favoring the KD group A Trusted Source

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The exact mechanism behind KD's weight loss effects is debated but may involve appetite regulation, protein satiety, or ketone body suppression of appetite A Trusted Source

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KD has also shown promise in managing type 2 diabetes mellitus, leading to weight loss and improved metabolic markers A Trusted Source

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However, it can have mixed effects on lipid profiles.

Some studies have reported an increase in LDL cholesterol and total cholesterol, while others have noted improvements in HDL cholesterol A Trusted Source

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Additionally, KD may lead to negative changes in lipoprotein sub-fractions, increasing the atherogenic risk A Trusted Source

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Despite its potential benefits, KD is not without risks.

Short-term side effects include vomiting, nausea, gastrointestinal discomfort, fatigue, dizziness, and changes in heart rate A Trusted Source

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Hypoglycemia and lethargy are common during KD initiation A Trusted Source

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Caution is advised when combining KD with other treatments, as it can lead to complications.

One case reported hepatic dysfunction in a patient using Valproate alongside KD A Trusted Source

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A significant concern is hyperlipidemia, where KD can lead to a rapid increase in LDL cholesterol and total cholesterol levels A Trusted Source

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One case reported severe hyperlipidemia in an individual following KD, which improved upon increasing carbohydrate intake A Trusted Source

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Moreover, KD has been associated with low bone mineral density, kidney stones, fractures, and hypercalcemia in some cases A Trusted Source

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Paleolithic Diet (PD)

Introduced in 1985 by Eaton and Konner and later published by Dr. Loren Cordain in 2010 A Trusted Source

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, the Paleolithic Diet (PD) has gained attention for its claims of improving health and combating modern diseases like obesity, cardiovascular disease, diabetes, and cancer.

Proponents argue that the modern diet, characterized by processed foods, dairy, grains, and legumes, is responsible for these ailments, and that our genetic makeup is better suited to a Paleolithic diet A Trusted Source

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Cordain's PD is defined by a set of rules, allowing unrestricted consumption of lean meats, fruits, and non-starchy vegetables while strictly avoiding dairy products, legumes, cereals, and processed foods .It places little emphasis on portion control and calorie counting.

The PD offers three adherence levels: entry-level, maintenance, and maximal weight loss, allowing individuals to choose based on their goals A Trusted Source

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Research on the PD has primarily focused on metabolic syndrome and insulin resistance.

It has shown benefits for specific groups, such as people with digestive disorders who benefit from eliminating dairy products.

Liberal consumption of fruits and vegetables may prevent inflammatory bowel diseases, but the diet's high meat content can increase the risk of such diseases A Trusted Source

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In the short term, the Paleolithic Diet can lead to significant weight loss, primarily due to the initial loss of water weight as it is low in carbohydrates.

Previous studies have reported a 4–6% reduction in total body weight within 10–12 weeks A Trusted Source

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However, most studies are based on short-term interventions, with only one lasting over 2 years.

In this study, post-menopausal obese women following the PD or Nordic Nutrition Recommendations (NNR) diet experienced reductions in waist circumference, fat mass, and weight after 24 months, regardless of the diet followed A Trusted Source

Mellberg C, Sandberg S, Ryberg M, Eriksson M, Brage S, Larsson C, et al. Long-term effects of a palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. (2014) 68:350–7. doi: 10.1038/ejcn.2013.290[PubMed Abstract, CrossRef Full Text, Google Scholar]
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The PD has shown promise in reducing total cholesterol (TC) levels in many studies, but results for high-density lipoprotein cholesterol (HDL-c) have been mixed A Trusted Source

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A Trusted Source

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A study of healthy adults showed TC, LDL-c, triglycerides, and mean arterial pressure reduction after 10 days on the PD A Trusted Source

Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. Metabolic and Physiologic Improvements from Consuming a Paleolithic, Hunter-Gatherer Type Diet. Eur J Clin Nutr. (2009) 63:947–55. doi: 10.1038/ejcn.2009.4[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Another trial found greater reductions in TC, triglycerides, and diastolic blood pressure after 2 weeks A Trusted Source

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However, some studies reported increased LDL-c, TC, TC:HDL-c, and decreased HDL-c values after following the PD for 10 weeks A Trusted Source

Smith MM, Trexler ET, Sommer AJ, Starkoff BE, Devor ST. Unrestricted paleolithic diet is associated with unfavorable changes to blood lipids in healthy subjects. Int J Exerc Sci. (2014) 7:128–39.[Google Scholar]
.

In most studies, fasting blood glucose remained unchanged A Trusted Source

Mellberg C, Sandberg S, Ryberg M, Eriksson M, Brage S, Larsson C, et al. Long-term effects of a palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. (2014) 68:350–7. doi: 10.1038/ejcn.2013.290[PubMed Abstract, CrossRef Full Text, Google Scholar]
A Trusted Source

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While some short-term studies did not measure HbA1c A Trusted Source

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A Trusted Source

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No significant change in inflammatory markers like CRP was reported A Trusted Source

Boers I, Muskiet FAJ, Berkelaar E, Schut E, Penders R, Hoenderdos K, et al. Favourable effects of consuming a palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study. Lipids Health Dis. (2014) 13:160–72. doi: 10.1186/1476-511X-13-160[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Despite its potential benefits, the Paleolithic Diet presents challenges.

It is expensive and demanding to follow compared to other diets A Trusted Source

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Beyond weight reduction and favorable effects on cardiometabolic profiles, the PD may have long-term consequences.

It is not nutritionally balanced as it excludes food groups like whole grains, legumes, and dairy products, potentially leading to micronutrient deficiencies.

Inadequate calcium intake is a concern, with PD providing about 50% less calcium than the daily requirement A Trusted Source

Osterdahl M, Kocturk T, Koochek A, Wandell PE. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr. (2008) 62:682–5. doi: 10.1038/sj.ejcn.1602790[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Decreased HDL-c has been observed in healthy adults and those with comorbidities following the PD.

In one study, type 2 diabetic patients following the PD experienced a significant reduction in HDL-c A Trusted Source

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In another study, healthy subjects on the PD for 10 weeks showed increased LDL-c, TC, TC:HDL-c ratios, and decreased HDL-c levels A Trusted Source

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Mediterranean Diet (MD)

The concept of the Mediterranean Diet (MD) originated in the 1950s through the work of Dr. Ancel Keys, who explored the link between diet and heart health.

He discovered variations in cardiovascular disease (CVD) mortality rates between Westerners and Europeans.

Interestingly, despite Europeans consuming a moderately high-fat diet, they had lower mortality and CVD incidence rates A Trusted Source

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Ancel Keys described the MD as a dietary pattern followed by people in Mediterranean regions.

It includes whole grains, legumes, fruits, vegetables, olive oil, fish, nuts, and allows moderate alcohol, dairy, and meat consumption (Keys, 1975) A Trusted Source

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The MD primarily relies on fish and plant-based foods for calories, with fats accounting for 30% of calories, mainly from polyunsaturated and monounsaturated fatty acids.

Carbohydrates provide 50–55% of calories from low glycemic index sources, while proteins contribute 15–20% of calories A Trusted Source

Kromhout D, Keys A, Aravanis C, Buzina R, Fidanza F, Giampaoli S, et al. Food Consumption Patterns in the 1960s in Seven Countries. Am J Clin Nutr. (1989) 49:889–94. doi: 10.1093/ajcn/49.5.889[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Extensively studied, the MD has proven to be nutritionally adequate for the general population and may prevent micronutrient deficiencies A Trusted Source

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Research suggests its potential in preventing and treating various chronic diseases, including non-alcoholic fatty liver disease (NAFLD), CVDs, metabolic syndrome, and certain cancers such as colorectal and breast cancer A Trusted Source

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Comparing weight loss effects, a 2-year trial found that the MD group had a mean weight loss of -4.4 ± 6 kg, second only to the Atkins Diet (AD) group with -4.7 ± 6.5 kg, while the low-fat diet (LFD) group had -2.9 ± 4.2 kg A Trusted Source

Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, et al. Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. N Engl J Med. (2008) 359:229–41. doi: 10.1056/NEJMoa0708681[PubMed Abstract, CrossRef Full Text, Google Scholar]
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In another trial, the low carbohydrate Mediterranean diet (LCM) group had the highest weight reduction, increased high-density lipoprotein cholesterol (HDL-c), improved low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), and HbA1c after 12 months A Trusted Source

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MD also shows promise in preventing cardiovascular events A Trusted Source

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and reducing the risk of non-tobacco-related cancers A Trusted Source

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While most MD studies are short-term, a study involving non-diabetic elderly individuals at higher risk of CVD found that MD with extra virgin olive oil reduced the risk of diabetes after 4.1 years A Trusted Source

Salas-Salvado J, Bullo M, Estruch R, Ros E, Covas M-I, Ibarrola-Jurado N, et al. Prevention of diabetes with mediterranean diets: a subgroup analysis of a randomized trial. Ann Intern Med. (2014) 160:1–10. doi: 10.7326/M13-1725[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Another 5-year clinical trial with type 2 diabetics or individuals at risk of CVD showed MD's significant reduction in central obesity A Trusted Source

Estruch R, Martínez-gonzález MA, Corella D, Salas-salvadó J, Chiva-blanch G, Fiol M. Effect of a high-fat mediterranean diet on bodyweight and waist circumference : a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. Lancet Diabetes Endocrinol. (2019) 7:e6–17. doi: 10.1016/S2213-8587(19)30074-9[CrossRef Full Text, Google Scholar]
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Vegetarian Diet (VD)

Vegetarian diets (VD) are characterized by the exclusion of meat, seafood, poultry, and sometimes other animal products like eggs, dairy, and honey.

There are four main types of VD: lacto-ovo-vegetarian, lactovegetarian, ovo-vegetarian, and vegan.

Each type has its own specific restrictions and allowances, but they all share the common trait of avoiding meat products A Trusted Source

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These dietary patterns have been gaining popularity, particularly in the Western world, for various reasons such as religious beliefs, ethical considerations, cultural factors, and health motivations A Trusted Source

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Numerous epidemiological studies have reported lower cardiometabolic risks in vegetarian populations.

For example, non-vegetarians have a higher prevalence of type 2 diabetes compared to vegetarians, with rates varying among different types of VD.

This lower risk is attributed to the low-glycemic-response nature of vegetarian diets, which include foods like beans, legumes, nuts, fruits, and vegetables A Trusted Source

Tonstad S, Yan R, Butler T, Fraser GE. Type of vegetarian diet, body weight, and prevalence of type 2 diabetes. Diabetes Care. (2009) 32:791–6. doi: 10.2337/dc08-1886[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Vegetarians, in general, tend to be more health-conscious and have a lower body mass index (BMI) compared to the general population.

The Seventh Day Adventist study revealed a lower mean BMI among vegans A Trusted Source

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Long-term studies have shown that vegans experience less weight gain than meat-eaters and fish eaters A Trusted Source

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Furthermore, vegetarian diets have been linked to a reduced risk of heart diseases and certain cancers, such as esophageal adenocarcinoma and gastric cardia or non-cardia adenocarcinoma, while also presenting better cardiometabolic profiles with lower BMI, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) A Trusted Source

Silvera SAN, Mayne ST, Risch H, Gammon MD, Vaughan TL, Chow W-H, et al. Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer. (2008) 123:852–60. doi: 10.1002/ijc.23544[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, et al. Meat, fish, and colorectal cancer risk: the European prospective investigation into cancer and nutrition. J Natl Cancer Inst. (2005) 97:906–16. doi: 10.1093/jnci/dji164[PubMed Abstract, CrossRef Full Text, Google Scholar]
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In terms of cancer prevention, a study suggested a protective effect of vegan diets against prostate cancer in the white population A Trusted Source

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High fiber intake in vegan diets may contribute to this protective effect.

However, findings regarding colorectal and breast cancer have been mixed, with some studies showing potential benefits A Trusted Source

Lagiou P, Talamini R, Samoli E, Lagiou A, Ahrens W, Pohlabeln H, et al. Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study. Int J Cancer. (2009) 124:2671–6. doi: 10.1002/ijc.24246[PubMed Abstract, CrossRef Full Text, Google Scholar]
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The benefits of VD may stem from the elimination of potentially harmful dietary components like animal protein, saturated fats, and cholesterol, as well as the addition of beneficial dietary components rich in fiber, phytochemicals, and antioxidants found in whole grains, legumes, nuts, fruits, and vegetables A Trusted Source

Silvera SAN, Mayne ST, Risch H, Gammon MD, Vaughan TL, Chow W-H, et al. Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer. (2008) 123:852–60. doi: 10.1002/ijc.23544[PubMed Abstract, CrossRef Full Text, Google Scholar]
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However, vegetarian diets can lead to fluctuations in micronutrient intake due to daily menu variations.

Depending on the type of VD, vegetarians may be at risk of deficiencies in essential nutrients such as calcium, zinc, iron, vitamin E, vitamin B12, essential fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA).

Some studies have reported that half of vegan participants were deficient in micronutrients compared to omnivores A Trusted Source

Gilsing, A.M.J., Crowe, F.L., Lloyd-Wright, Z., Sanders, T.A.B., Appleby, P.N., Allen, N.E., Key, T.J. Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians, and vegans: results from a cross-sectional analysis of the EPIC-oxford cohort study. Eur J Clin Nutr. (2011) 64:933–9. doi: 10.1038/ejcn.2010.142.Serum[CrossRef Full Text, Google Scholar]
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Vitamin B12 deficiency is common among vegetarians, particularly vegans, as plant sources lack this essential nutrient.

Vegetarians may also experience lower bone mineral density due to the suboptimal intake of calcium, making them more susceptible to bone fractures A Trusted Source

Craig, W.J., Mangels, A.R. Position of the American dietetic association: vegetarian diets. J Am Diet Assoc. (2009) 109:1266–82. doi: 10.1016/j.jada.2009.05.027[PubMed Abstract, CrossRef Full Text, Google Scholar]
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To mitigate these deficiencies, vegetarians often require vitamin B12 and vitamin D supplements, especially pregnant and lactating vegan mothers to prevent deficiencies in their babies A Trusted Source

Dror, D.K., Allen, L.H. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev. (2008) 66:250–5. doi: 10.1111/j.1753-4887.2008.00031.x[PubMed Abstract, CrossRef Full Text, Google Scholar]
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While VD can be nutritionally adequate and beneficial for chronic disease prevention and treatment, individualized plans that fulfill micronutrient requirements should be developed with the guidance of healthcare professionals A Trusted Source

Marsh K, Zeuschner C, Saunders A. Health implications of a vegetarian diet: a review. Am J Lifestyle Med. (2012) 6:250–67. doi: 10.1177/1559827611425762[CrossRef Full Text, Google Scholar]
.

Intermittent Fasting (IF)

Intermittent Fasting (IF) is making waves as a popular and effective method for shedding pounds.

Unlike traditional weight loss programs that focus on calorie restriction, IF revolves around scheduled eating patterns.

Key features of IF include periods of fasting followed by regular eating, with various versions such as Alternate Day Fasting (ADF), the 5:2 diet, Periodic Fasting (PF), and Time-Restricted Feeding (TRF).

The frequency and duration of fasting cycles vary across these methods.

For instance, ADF involves 20-hour fasting periods alternating with normal eating over 15 days, resulting in increased glucose uptake and lipolysis in adipose tissues A Trusted Source

Halberg, N., Henriksen, M., Söderhamn, N., Stallknecht, B., Ploug, T., Schjerling, P., Dela, F. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol. (2005) 99:2128–36. doi: 10.1152/japplphysiol.00683.2005[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Similarly, a 22-day fasting regimen on alternate days led to a 4% reduction in initial fat mass and a 2.5% decrease in body weight among non-obese subjects A Trusted Source

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Research into IF's impact on biomarkers revealed acute changes in response to fasting.

A randomized crossover trial found that fasting led to increased hemoglobin, hematocrit, red blood cell count, human growth hormone, and high-density lipoprotein cholesterol (HDL-c).

Simultaneously, there were decreases in body weight, bicarbonates, and triglycerides (TGs).

Cholesterol and human growth hormone returned to baseline after 48 hours A Trusted Source

Horne BD, Muhlestein JB, Lappe DL, May HT, Carlquist JF, Galenko O, et al. Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences. Nutr Metab Cardiovasc Dis. (2013) 23:1050–7. doi: 10.1016/j.numecd.2012.09.007[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Night-time fasting (NTF) has been linked to lower energy intake and weight loss.

In a study, healthy young men practiced 9-hour NTF for two weeks and consumed fewer calories during this phase compared to controlled conditions.

Significant differences in weight change were observed, with NTF resulting in a 0.4 kg weight loss compared to a 0.6 kg gain in the control group A Trusted Source

LeCheminant JD, Christenson E, Bailey BW, Tucker LA. Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study. Br J Cancer. (2013) 110:2108–13. doi: 10.1017/S0007114513001359[PubMed Abstract, CrossRef Full Text, Google Scholar]
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In a three-month randomized trial, young overweight premenopausal women were divided into two groups: fasting for two consecutive days a week or fasting every day.

Both approaches were effective for weight loss and showed improvements in cardiovascular disease, cancer, and diabetes risk markers, such as reduced leptin levels, lowered inflammatory markers, decreased fasting insulin, improved insulin resistance, better blood pressure, and favorable lipid profiles A Trusted Source

Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : a randomized trial in young overweight women. Int J Obes. (2011) 35:714–27. doi: 10.1038/ijo.2010.171[PubMed Abstract, CrossRef Full Text, Google Scholar]
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IF also affects appetite by influencing appetite-regulating hormones A Trusted Source

Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : a randomized trial in young overweight women. Int J Obes. (2011) 35:714–27. doi: 10.1038/ijo.2010.171[PubMed Abstract, CrossRef Full Text, Google Scholar]
A Trusted Source

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It has the potential to improve insulin resistance, leading to better glycemic control, decreased fasting glucose levels, reduced BMI, fat mass, and increased adiponectin A Trusted Source

Cho Y, Hong N, Kim K, Cho SJ, Lee M, Lee Y, et al. The effectiveness of intermittent fasting to reduce body mass index and glucose metabolism: a systematic review and meta-analysis. J Clin Med. (2019) 8:1645–55. doi: 10.3390/jcm8101645[PubMed Abstract, CrossRef Full Text, Google Scholar]
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However, IF may have potential drawbacks for normal-weight individuals.

Prolonged fasting, whether ADF or periodic fasting, can induce lipolysis and increase free fatty acids (FFA).

Such fluctuations, three times greater than those seen after overnight fasting, can reduce insulin sensitivity and glucose-simulated insulin response A Trusted Source

Salgin B, Marcovecchio ML, Humphreys SM, Hill N, Chassin LJ, Lunn DJ, et al. Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects. Am J Physiol Endocrinol Metab. (2009) 296:E454–61. doi: 10.1152/ajpendo.90613.2008[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Detox Diets (DDs)

Detoxification diets, commonly known as detox diets or DDs, have a long history dating back to ancient cultures like the Greeks, Romans, Indians, and Native Americans.

These diets employ various methods to eliminate toxins from the body, including fasting, saunas, herbs, exercise, and more A Trusted Source

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Modern detox diets are short-term interventions designed for toxin elimination, health enhancement, and weight management.

They typically involve approaches like calorie restriction, dietary modifications, juice fasting, and may include additional supplements, diuretics, or laxatives A Trusted Source

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Despite their popularity, detox diets lack extensive scientific investigation.

Existing studies have limitations such as small sample sizes, self-reporting, and a lack of control groups.

Moreover, the precise mechanisms by which these diets eliminate toxins remain unclear.

This is a concern as the human body, through the liver and kidneys, efficiently removes both exogenous and endogenous toxins, with additional excretion occurring through sweat and sebum A Trusted Source

Genuis SJ, Birkholz D, Rodushkin I, Beesoon S. Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements. Arch Environ Contam Toxicol. (2011) 61:344–57. doi: 10.1007/s00244-010-9611-5[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Currently, there is no clinical evidence to definitively support or refute the effectiveness of commercial detox diets for weight loss.

Dieting in general has a success rate of only 20%, partly due to the body's natural mechanisms to counteract weight loss, including metabolic rate reduction and increased appetite A Trusted Source

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Stress-induced appetite stimulation, driven by elevated cortisol levels, can also lead to weight gain A Trusted Source

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Many detox diets are liquid-based, low in calories, and lack essential nutrients.

Some provide as little as 19g of protein and 860 kcal/day, falling far below recommended dietary requirements A Trusted Source

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This nutrient deficiency, coupled with potential stress induction and increased appetite, can make it challenging to lose weight on detox diets, potentially leading to binge eating and weight gain.

Moreover, detox products often lack regulation and quality control.

An alarming case in Spain involved a man who suffered from manganese intoxication after ingesting Epsom salt during a liver cleansing diet due to a labeling error A Trusted Source

Sanchez B, Casalots-Casado J, Quintana S, Arroyo A, Martin-Fumadoc C, Galtes I. Fatal manganese intoxication due to an error in the elaboration of epsom salts for a liver cleansing diet. Forensic Sci Int. (2012) 223:e1–14. doi: 10.1016/j.forsciint.2012.07.010[PubMed Abstract, CrossRef Full Text, Google Scholar]
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Final Thoughts: Making Smart Diet Choices

Fad diets promise rapid weight loss and improved appearance, but they often lack long-term sustainability.

While they can have some health benefits, these diets typically involve unrealistic food combinations and may eliminate essential food groups.

For individuals with underlying health conditions, there can be risks associated with rapid weight loss.

Research on these diets is limited and often inconclusive, with high dropout rates.

To ensure public safety and inform individuals about potential long-term consequences, more randomized controlled trials of extended duration are needed.

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